The Women's Murder Club pits four San Francisco women professionals against a serial killer who is stalking and murdering newlyweds. Lindsay Boxer is a homicide inspector who has received very bad news. She deals with it by immersing herself in her newest case and soliciting the personal as well as professional support of her closest friend, who happens to be the city's medical examiner. The two women, along with a reporter and an assistant DA, form an unlikely alliance.